THE IMPACT OF BLOCKS TRADES IN THE UNDERLYING MARKET ON OPTION PRICES: EVIDENCE FROM THE ASX

This dissertation examines the impact a block trade in the underlying stock market has on options listed on that stock in the options market. There is significant debate in previous literature in regards to which market leads, and which market is preferred by informed traders. This thesis contributes to, and extends previous literature, by examining the relationship between stocks and options around block trades in a different geographical setting. Furthermore, by using a combined dataset provided by SIRCA and the Australian Securities Exchange, this dissertation is able to identify individual brokers executing block trades and analyse their activity in the options market. This unique dataset allows a direct test of the “inter-market front-running” hypothesis proposed by in prior literature. Results from this dissertation are consistent with previous literature, and indicate that the stock market leads the options market by as much as fifteen minutes. Analysis of Broker ID’s confirms that there is no evidence of any inter-market front-running

Youthmen with big man mentality: An exploration and analysis of the narratives of young offenders in Trinidad and Tobago.

There is an ongoing moral panic about ‘the’ juvenile delinquent in Trinidad and Tobago. The media present, with increasing regularity, stories about problematic youth—particularly young men—giving the impression that youth crime is spiralling out of control, when official statistical evidence suggests otherwise. Research into youth offending in Trinidad and Tobago has been mainly quantitative, considering the risks and protective factors associated with delinquency and desistance. The extant research also analyses and discusses the data uncovered within the framework of Western criminological theories. Little attempt is made to use, adapt, or develop theory in the Caribbean or Trinbagonian context in which the data was produced. The present study addresses the dearth of qualitative data on young offenders in Trinidad and Tobago by presenting the narratives of a census population of convicted juvenile offenders housed at the Youth Training Centre in Trinidad. These narratives are analysed and interpreted within the socio-economic, cultural and historical context in which these accounts were produced, taking up a 40-year-old call for the development of a ‘Caribbean Criminology’. The main purpose of this project was to gain an understanding of the subjective lived experiences of incarcerated young men in Trinidad and Tobago; how they feel, think, act and make sense of the world. I discuss the implications of the narratives presented with regard to broader sociological-criminological questions about state legitimacy and procedural justice and within the context of the families and communities from which my participants come. My findings offer insight into stigmatised communities and suggest the need for a reconceptualisation of poverty as a structural deficit rather than an individual failing, and a need for state officials to recognise the social and cultural injustice that have blocked opportunities for a number of citizens

Reestructuración comercial nuevo mercado modelo en la ciudad de Huarmey

El tema pertenece a la arquitectura Comercial y esta direccionado a la reubicación y mejoramiento de la infraestructura del mercado modelo, generando oportunidades a los distintos productores y comerciantes locales de la ciudad de Huarmey. Se busca brindar todos los servicios comerciales que carecen en la ciudad, dado que no cuentan con una infraestructura adecuada y a su vez no cuenta con centros comerciales, centros bancarios, etc.; esto quie- re decir que se implementaran usos complementarios al proyecto. En respuesta a lo señalado se plantea un Nuevo Mercado Modelo en la ciudad de Huarmey para que esté mejore la infraestructura comercial, haya una mejor exposición y venta de los productos, se creara nuevos espacios públicos para residentes y visitantes. El proyecto estará emplazado en el eje comercial más importante de la ciudad la av. El Olivar y la Pana- mericana Norte, lo que favorece visualmente, dado que estas dos avenidas tienen mayor flujo peatonal y vehicular. En la actualidad se ve reflejado la falta de servicios en el mercado modelo de Huarmey, y esto se mani- fiesta en los distintos puntos de la ciudad con mercados itinerantes en mal estado, poniendo en peligro al usuario y comerciante

Reestructuración comercial nuevo mercado modelo en la ciudad de Huarmey

El tema pertenece a la arquitectura Comercial y esta direccionado a la reubicación y mejoramiento de la infraestructura del mercado modelo, generando oportunidades a los distintos productores y comerciantes locales de la ciudad de Huarmey. Se busca brindar todos los servicios comerciales que carecen en la ciudad, dado que no cuentan con una infraestructura adecuada y a su vez no cuenta con centros comerciales, centros bancarios, etc.; esto quie- re decir que se implementaran usos complementarios al proyecto. En respuesta a lo señalado se plantea un Nuevo Mercado Modelo en la ciudad de Huarmey para que esté mejore la infraestructura comercial, haya una mejor exposición y venta de los productos, se creara nuevos espacios públicos para residentes y visitantes. El proyecto estará emplazado en el eje comercial más importante de la ciudad la av. El Olivar y la Pana- mericana Norte, lo que favorece visualmente, dado que estas dos avenidas tienen mayor flujo peatonal y vehicular. En la actualidad se ve reflejado la falta de servicios en el mercado modelo de Huarmey, y esto se mani- fiesta en los distintos puntos de la ciudad con mercados itinerantes en mal estado, poniendo en peligro al usuario y comerciante

Does publishing during the doctorate influence completion time? A quantitative study of doctoral candidates in Australia.

Aim/Purpose: This paper investigates the association between publishing during doctoral candidature and completion time. The effects of discipline and of gaining additional support through a doctoral cohort program are also explored. Background: Candidates recognize the value of building a publication track record to improve their career prospects yet are cognizant of the time it takes to publish peer-reviewed articles. In some institutions or disciplines, there is a policy or the expectation that doctoral students will publish during their candidature. However, doctoral candidates are also under increasing pressure to complete their studies within a designated timeframe. Thus, some candidates and faculty perceive the two requirements – to publish and to complete on time – as mutually exclusive. Furthermore, where candidates have a choice in the format that the PhD submission will take, be it by monograph, PhD-by-publication, or a hybrid thesis, there is little empirical evidence available to guide the decision. This paper provides a quantitative analysis of the association between publishing during candidature and time-to-degree and investigates other variables associated with doctoral candidate research productivity and efficiency. Methodology: Multivariate logistic regression analyses were used to examine the predictors (discipline [field of research], gender, age group, domestic or international student status, and belonging to a cohort program) of doctoral candidate research productivity and efficacy. Research productivity was quantified by the number of peer-reviewed journal articles that a candidate published as a primary author during and up to 24 months after thesis submission. Efficacy (time-to-degree) was quantified by the number of Full-Time Equivalent (FTE) years of candidature. Data on 1,143 doctoral graduates were obtained from a single Australian university for the period extending from 2000 to 2020. Complete publication data were available on 707 graduates, and time-to-degree data on 664 graduates. Data were drawn from eight fields of research, which were grouped into the disciplines of health, biological sciences, agricultural and environmental sciences, and chemical, earth, and physical sciences. Contribution: This paper addresses a gap in empirical literature by providing evidence of the association between publishing during doctoral candidature and time-to-degree in the disciplines of health, biological sciences, agricultural and environmental sciences, and chemical, earth, and physical sciences. The paper also adds to the body of evidence that demonstrates the value of belonging to a cohort pro-gram for doctoral student outcomes. Findings: There is a significant association between the number of articles published and median time-to-degree. Graduates with the highest research productivity (four or more articles) exhibited the shortest time-to-degree. There was also a significant association between discipline and the number of publications published during candidature. Gaining additional peer and research-focused support and training through a cohort program was also associated with higher research productivity and efficiency compared to candidates in the same discipline but not in receipt of the additional support. Recommendations for Practitioners: While the encouragement of candidates to both publish and complete within the recommended doctorate timeframe is recommended, even within disciplines characterized by high levels of research productivity, i.e., where publishing during candidature is the "norm," the desired levels of student research productivity and efficiency are only likely to be achieved where candidates are provided with consistent writing and publication-focused training, together with peer or mentor support. Recommendations for Researchers: Publishing peer-reviewed articles during doctoral candidature is shown not to adversely affect candidates' completion time. Researchers should seek writing and publication-focused support to enhance their research productivity and efficiency. Impact on Society: Researchers have an obligation to disseminate their findings for the benefit of society, industry, or practice. Thus, doctoral candidates need to be encouraged and supported to publish as they progress through their candidature. Future Research: The quantitative findings need to be followed up with a mixed-methods study aimed at identifying which elements of publication and research-focused sup-port are most effective in raising doctoral candidate productivity and efficacy

Lessons learned while searching for meaning in doctoral completion metrics: An intra-institution case study

For institutions intent on improving their research student outcomes, it is important to identify the variables most strongly associated with timely or tardy completions, which the university has the potential to influence or amend. For this to occur the analyses of doctoral completion times need to be conducted at an institution or discipline level. However, conducting meaningful analyses of doctoral completion data is a complex undertaking fraught with potential problems. This paper uses an intra-institution case study to reflect on and illustrate how different meanings can emerge from data analysis, depending on the statistical approach used to analyse the data. The paper outlines the lessons learned during data analysis, and the implications for doctoral education. The findings also point to potential marketing opportunities for research institutions

Evaluación de la conducta alimentaria en adultos de 20-40 años del municipio de Bucaramanga

Los trastornos de la conducta alimentaria (TCA). Es una enfermedad de la salud mental que afectan psicológica y físicamente a la persona, tanto adolescentes como a mujeres jóvenes. Se puede estar atentos a los factores de riesgo tanto individuales como socioculturales y desde el punto de vista de los profesionales de la salud, existen instrumentos no sólo para establecer un diagnóstico sino aprovechar su uso como herramienta para una detección temprana de este trastorno. Investigaciones evidencian que, las preocupaciones de la imagen corporal y otras conductas influyen en el desarrollo y permanencia de este trastorno. Los valores cobran cada vez protagonismo, y el fruto de esto se ve reflejada en una excesiva preocupación por su aspecto físico, encaminadas a un ideal estético socialmente establecido, el conocimiento de estos múltiples factores de desarrollo de los TCA y su especial injerencia con los medios potenciadores de estas patologías ya que motivan al análisis de esta investigación.Research shows that body image concerns and other behaviors influence the development and persistence of this disorder. Values are increasingly taking center stage, and the fruit of this is reflected in an excessive concern for their physical appearance, aimed at a socially established aesthetic ideal, knowledge of these multiple factors of development of eating disorders and their special interference with the media. enhancers of these pathologies since they motivate the analysis of this research.Introducción 4. -- Planteamiento del problema 7. --Pregunta problema 9. -- Justificación 10. -- Objetivo general 12. -- Objetivos específicos 12. -- Marco Referencial 13. -- Antecedentes investigativos 13. --Internacionales 13. -- Nacionales 15. -- Locales 17. -- Marco conceptual 19. -- Marco legal 27. -- Marco teórico 30. -- Metodología 39. -- Diseño 39. -- Enfoque cuantitativo 40. -- Población 40. --Tipo de muestreo 40. -- Criterios de inclusión y exclusión 41. -- Instrumentos 42. -- El EDI-3 - El Inventario de trastornos de la conducta alimentaria-3 42. -- Plan De Análisis De Datos 49. -- Resultados 50. -- Resultados Sociodemográficos 50. -- Resultados de la prueba Edi-3 56. -- Consecuencias 72. --Recomendaciones 74. -- Conclusión 80. -- Referencias 81 Lista de Tablas. -- Tabla 1 Estadísticas 9. -- Tabla 2 Cronograma 46. -- Tabla 3 Presupuesto 47. -- Tabla 4 Resultados generales en los datos sociodemográficos. 53 Lista de Gráficas. -- Gráfica 1 Género 48. -- Gráfica 2 Rango de edad 49. -- Gráfica 3 Estrato social 50. -- Gráfica 4 Con quién vive 51. -- Gráfica 5 Nivel educativo 51. -- Gráfica 6 Trabaja 52. -- Gráfica 7 Hijos 53. -- Gráfica 8 Insatisfacción corporal (BD) 55. -- Gráfica 9 Obsesión por la delgadez (DT) 56. -- Gráfica 10 Bulimia (B) 5

BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling

Ovarian cancer; ProteomicsCáncer de ovarios: ProteómicaCàncer d'ovaris; ProteòmicaDespite recent advances in the management of BRCA1 mutated high-grade serous ovarian cancer (HGSC), the physiology of these tumors remains poorly understood. Here we provide a comprehensive molecular understanding of the signaling processes that drive HGSC pathogenesis with the addition of valuable ubiquitination profiling, and their dependency on BRCA1 mutation-state directly in patient-derived tissues. Using a multilayered proteomic approach, we show the tight coordination between the ubiquitination and phosphorylation regulatory layers and their role in key cellular processes related to BRCA1-dependent HGSC pathogenesis. In addition, we identify key bridging proteins, kinase activity, and post-translational modifications responsible for molding distinct cancer phenotypes, thus providing new opportunities for therapeutic intervention, and ultimately advance towards a more personalized patient care.This work was supported by the PhD4MD collaborative research program between the Vall d’Hebron Research Institute (VHIR) and the Centre for Genomic Regulation (CRG). The CRG/UPF Proteomics Unit is part of the Spanish Infrastructure for Omics Technologies (ICTS OmicsTech) and it is a member of the ProteoRed PRB3 consortium which is supported by grant PT17/0019 of the PE I+D+i 2013-2016 from the Instituto de Salud Carlos III (ISCIII) and ERDF. We acknowledge support from the Spanish Ministry of Science, Innovation and Universities, (CTQ2016-80364-P and “Centro de Excelencia Severo Ochoa 2013-2017”, SEV-2012-0208), and “Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya” (2017SGR595 and 2017SGR1661). This project has also received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 823839 (EPIC-XS). It has also been supported by grants from the Instituto Carlos III (PI15/00238, PI18/01017, PI21/00977), the Miguel Servet Program (CP13/00158 and CPII18/00027) and the Ministerio de Economía y Competitividad y Fondos FEDER (RTC-2015-3821-1). The authors are grateful to the team members of the Proteomics Unit at the Centre for Genomic Regulation, the Biomedical Research Group in Gynecology at the Vall d’Hebron Institute, the Gynecological Oncology Unit at the Vall d’Hebron Hospital and the Biomedical Research Group in Urology at the Vall d’Hebron Institute for their assistance

Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices.

OBJECTIVE: To study the difference in gene expression between human papillomavirus (HPV)-positive and HPV-negative oral cavity and oropharyngeal squamous cell carcinoma (OSCC). DESIGN: We used Affymetrix U133 plus 2.0 arrays to examine gene expression profiles of OSCC and normal oral tissue. The HPV DNA was detected using polymerase chain reaction followed by the Roche LINEAR ARRAY HPV Genotyping Test, and the differentially expressed genes were analyzed to examine their potential biological roles using the Ingenuity Pathway Analysis Software, version 5.0. SETTING: Three medical centers affiliated with the University of Washington. PATIENTS: A total of 119 patients with primary OSCC and 35 patients without cancer, all of whom were treated at the setting institutions, provided tissues samples for the study. RESULTS: Human papillomavirus DNA was found in 41 of 119 tumors (34.5%) and 2 of 35 normal tissue samples (5.7%); 39 of the 43 HPV specimens were HPV-16. A higher prevalence of HPV DNA was found in oropharyngeal cancer (23 of 31) than in oral cavity cancer (18 of 88). We found no significant difference in gene expression between HPV-positive and HPV-negative oral cavity cancer but found 446 probe sets (347 known genes) differentially expressed in HPV-positive oropharyngeal cancer than in HPV-negative oropharyngeal cancer. The most prominent functions of these genes are DNA replication, DNA repair, and cell cycling. Some genes differentially expressed between HPV-positive and HPV-negative oropharyngeal cancer (eg, TYMS, STMN1, CCND1, and RBBP4) are involved in chemotherapy or radiation sensitivity. CONCLUSION: These results suggest that differences in the biology of HPV-positive and HPV-negative oropharyngeal cancer may have implications for the management of patients with these different tumors